Triple-Quantum-Filtered Sodium Imaging at 9.4 Tesla

Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity

Abstract

PURPOSE:

Efficient acquisition of triple-quantum-filtered (TQF) sodium images at ultra-high field (UHF) strength.

METHODS:

A three-pulse preparation and a stack of double-spirals were used for the acquisition of TQF images at 9.4 Tesla. The flip angles of the TQ preparation were smoothly reduced toward the edge of k-space along the partition-encoding direction. In doing so, the specific absorption rate could be reduced while preserving the maximal signal intensity for the partitions most relevant for image contrast in the center of k-space. Simulations, phantom and in vivo measurements were used to demonstrate the usefulness of the proposed method.

RESULTS:

A higher sensitivity (∼20%) was achieved compared to the standard acquisition without flip angle apodization. Signals from free sodium ions were successfully suppressed irrespective of the amount of apodization used. B0 corrected TQF images with a nominal resolution of 5 × 5 × 5 mm3 and an acceptable signal-to-noise ratio could be acquired in vivo within 21 min.

CONCLUSION:

Conventional TQF in combination with flip angle apodization permits to exploit more efficiently the increased sensitivity available at 9.4T. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc.

Authors:
Mirkes C, Shajan G, Bause J, Buckenmaier K, Hoffmann J, Scheffler K.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/25846242