Research Topic 3
Impaired CNS control of metabolism and therapeutic intervention
Work Package 11:
Molecular imaging and targeting of hypothalamic inflammation in obestiy
Work Package 12:
Tsch����p (collaborators: Wurst)
Dual-specificity phosphatase 8 as molecular link between hypothalamic inflammation and systemic glucose intolerance.
Work Package 13:
Wurst (collaborators: Westmeyer, Tschöp, Hrabe de Angelis, Lickert, Götz)
Dissecting the role of central CRH signalling for hypothalamic inflammatory and morphological processes promoting obesity and diabetes.
Work Package 14:
Westmeyer (collaborators: Tschöp, Wurst)
Multi-modal imaging and targeted drug delivery to study diet-induced hypothalamic morphological changes.
Work Package 15:
Hofmann (collaborators: Wurst, Tschöp, Brüning, Götz, Androutsellis-Theotokis, Westmeyer)
Gender-specific effects of endurance training on diet-induced obesity.
Work Package 16:
Involvement of a newly discovered endogenous neural stem cell in the CNS control of metabolic diseases.
Work Package 17:
Götz (collaborators: Tschöp)
Impact of metabolic diseases on adult neural stem cells in hypothalamic metabolism control centers.
Work Package 18:
Hallschmid, Lehnert, Häring (collaborators: Yeo, Brüning, Mewes, Scheffler)
Brain insulin action in the control of systemic glucose and energy }etabolism.
Work Package 19:
Spranger, Krude, Biebermann, Haynes
Interaction between nutrition and the endocrine network regulating whole body energy homeostasis.