Research Topic 2: Environmental Metabolic Diseases – Integrating central and peripheral processes

ICEMED Publications – Research Topic 2: Environmental Metabolic Diseases – Integrating central and peripheral processes; Leader: Matthias Blüher

WP 7: Control of peripheral metabolic signaling by the CNS; Leader:
Stefan Herzig

Ashley Eheim & Dasa Medrikova & Stephan Herzig: Immune cells and metabolic dysfunction. Semin Immunopathol (2014) 36(1):13–25.
Karin Mössenböck, Alexandros Vegiopoulos, Adam J. Rose1, Tjeerd P. Sijmonsma1, Stephan Herzig, Tobias Schafmeier: Browning of White Adipose Tissue Uncouples Glucose Uptake from Insulin Signaling. PLoS ONE (2014) 9(10): e110428.

Diaz M.B, Herzig S., Vegiopoulos A.: Thermogenic adipocytes: from cells to physiology and medicine. Metabolism. (2014) 63(10):1238-1249.

De Guia R.M., Rose A.J., Herzig S.: Glucocorticoid hormones and energy homeostasis. Horm Mol Biol Clin Investig. (2014) 19(2):117-128.

Roldan M de Guia, Adam J Rose, Anke Sommerfeld, Oksana Seibert, Daniela Strzoda, Annika Zota, Yvonne Feuchter, Anja Krones-Herzig, Tjeerd Sijmonsma, Milen Kirilov, Carsten Sticht, Norbert Gretz, Geesje Dallinga-Thie, Sven Diederichs, Nora Klöting, Matthias Blüher, Mauricio Berriel Diaz & Stephan Herzig: microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis. The EMBO Journal (2015) 34(3): 344 – 360.

Rohm M., et al: Peptide-mediated maintenance of adipose tissue integrity protects against cancer cachexia. In revision.

WP 8: Cross talk between the brain and adipose tissue; Leaders: Michael Stumvoll, Matthias Blüher, Ingo Bechmann

Kälin S., Heppner F.L., Bechmann I., Prinz M., Tschöp M.H., Yi C.X.: Hypothalamic innate immune reaction in obesity. Nat. Rev. Endocrinol. (2015) 11(6):339 – 351.

Marco Koch, Luis Varela, Jae Geun Kim, Jung Dae Kim, Francisco Hernandez, Stephanie E Simonds, Carlos M Castorena, Claudia R Vianna, Joel K Elmquist, Yury M Morozov, Pasko Rakic, Ingo Bechmann, Michael A Cowley, Klara Szigeti-Buck, Marcelo O Dietrich, Xiao-Bing Gao, Sabrina Diano, and Tamas L Horvath: Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature (2015) 519(7541):45 – 50.

Kerstin Immig, Martin Gericke, Franziska Menzel, Felicitas Merz, Martin Krueger, Fridtjof Schiefenhövel, Andreas Lösche, Kathrin Jäger, Uwe-Karsten Hanisch, Knut Biber, and Ingo Bechmann: CD11c-Positive Cells from Brain, Spleen, Lung, and Liver Exhibit Site-Specific Immune Phenotypes and Plastically Adapt to New Environments. GLIA (2015) 63(4):611–625.

Wolfgang J Streit, Qing-Shan Xue, Jasmin Tischer and Ingo Bechmann: Microglial pathology. Acta Neuropathologica Communications (2014) 2:142.

Kosacka J, Kern M, Klöting N, Paeschke S, Rudich A, Haim Y, Gericke M, Serke H, Stumvoll M, Bechmann I, Nowicki M, Blüher M.: Autophagy in adipose tissue of patients with obesity and type 2 diabetes. Mol Cell Endocrinol. (2015) 409: 21-32.

Johannie du Plessis, Jos van Pelt, Hannelie Korf, Chantal Mathieu, Bart van der Schueren, Matthias Lannoo, Tom Oyen, Baki Topal, Gary Fetter, Simon Nayler, Tessa van der Merwe, Petra Windmolders, Luc Van Gaal, An Verrijken, Guy Hubens, Martin Gericke, David Cassiman, Sven Francque, Frederik Nevens, and Schalk van der Merwe: Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease. Gastroenterology (2015) 149(3): 635–648.

Gericke M., Weyer U., Braune J., Bechmann I., Ellers J.,: A method for long-term live imaging of tissue macrophages in adipose tissue explants. Am J Physiol Endocrinol Metab. (2015) 308(11): E1023-33.

Karsten Mueller, Harald E. Möller, Annette Horstmann, Franziska Busse, Jöran Lepsien, Matthias Blüher, Michael Stumvoll, Arno Villringer, and Burkhard Pleger: Physical exercise in overweight to obese individuals induces metabolic-and neurotrophic-related structural brain plasticity. Front. Hum. Neurosci. (2015) 9: 372.

Roldan M de Guia, Adam J Rose, Anke Sommerfeld, Oksana Seibert, Daniela Strzoda, Annika Zota, Yvonne Feuchter, Anja Krones-Herzig, Tjeerd Sijmonsma, Milen Kirilov, Carsten Sticht, Norbert Gretz, Geesje Dallinga-Thie, Sven Diederichs, Nora Klöting, Matthias Blüher, Mauricio Berriel Diaz & Stephan Herzig: microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis. The EMBO Journal (2015) 34: 344–360.

Sarah M. Turpin, Hayley T. Nicholls, Diana M. Willmes, Arnaud Mourier, Susanne Brodesser, Claudia M. Wunderlich, Jan Mauer, Elaine Xu, Philipp Hammerschmidt, Hella S. Brönneke, Aleksandra Trifunovic, Giuseppe LoSasso, F. Thomas Wunderlich, Jan-Wilhelm Kornfeld, Matthias Blüher, Martin Krönke, and Jens C. Brüning: Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance. Cell Metabolism (2014) 20(4): 678–686.

Mardinoglu A, Heiker JT, Gärtner D, Schön MR, Flehmig G, Krohn K, Klöting N, Fasshauer M, Stumvoll M, Nielsen J, Blüher M: Extensive weight loss in a two step bariatric surgery strategy reveals distinct gene expression profile changes in human subcutaneous and visceral adipose tissue, Scientific Reports. (2015) Oct 5; 5:14841

Nico Hesselbarth, Chiara Pettinelli, Martin Gericke, Claudia Berger, Anne Kunath, Michael Stumvoll, Matthias Blüher, Nora Klöting: Tamoxifen affects glucose and lipid metabolism parameters, causes browning of subcutaneous adipose tissue and transient body composition changes in C57BL/6NTac mice. Biochemical and Biophysical Research Communications (2015) 464(3): 724–729.

Fasshauer M., Blüher M.: Adipokines in health and disease. Trends Pharmacol Sci. (2015) 36(7): 461-470.

Anja Knigge, Nora Klöting, Michael R. Schön, Arne Dietrich, Mathias Fasshauer, Daniel Gärtner, Tobias Lohmann, Miriam Dreßler, Michael Stumvoll, Peter Kovacs, Matthias Blüher: ADCY5 Gene Expression in Adipose Tissue Is Related to Obesity in Men and Mice. PLOS ONE (2015) 10(3): e0120742.

Aimo Kannt & Anja Pfenninger & Lenore Teichert & Anke Tönjes & Arne Dietrich & Michael R. Schön & Nora Klöting & Matthias Blüher: Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance. Diabetologia (2015) 58(4): 799–808.

Nicole Lakowa, Nhu Trieu, Gesine Flehmig, Tobias Lohmann, Michael R. Schön, Arne Dietrich, Philip Helge Zeplin, Stefan Langer, Michael Stumvoll, Matthias Blüher, Nora Klöting: Telomere length differences between subcutaneous and visceral adipose tissue in humans. Biochemical and Biophysical Research Communications (2015) 457(3): 426 – 432.

James C. Lo, Sanda Ljubicic, Barbara Leibiger, Matthias Kern, Ingo B. Leibiger, Tilo Moede, Molly E. Kelly, Diti Chatterjee Bhowmick, Incoronata Murano, Paul Cohen, Alexander S. Banks, Melin J. Khandekar, Arne Dietrich, Jeffrey S. Flier, Saverio Cinti, Matthias Blüher, Nika N. Danial, Per-Olof Berggren, and Bruce M. Spiegelman: Adipsin is an Adipokine that Improves β Cell Function in Diabetes. Cell (2014) 158(1): 41–53.

Gesine Flehmig, Markus Scholz, Nora Klöting, Mathias Fasshauer, Anke Tönjes, Michael Stumvoll, Byung-Soo Youn, Matthias Blüher: Identification of Adipokine Clusters Related to Parameters of Fat Mass, Insulin Sensitivity and Inflammation. PLoS ONE (2014) 9(6): e99785.

Aurelie Cotillard, Christine Poitou, Adriana Torcivia, Jean-Luc Bouillot, Arne Dietrich, Nora Klöting, Cécile Grégoire, Karine Lolmede, Matthias Blüher, and Karine Clément: Adipocyte Size Threshold Matters: Link with Risk of Type 2 Diabetes and Improved Insulin Resistance After Gastric Bypass. J Clin Endocrinol Metab, (2014) 99(8): E1466–E1470.

Matthias Kern, Joanna Kosacka, Nico Hesselbarth, Julia Brückner, John T. Heiker, Gesine Flehmig, Ingrid Klöting, Peter Kovacs, Madlen Matz-Soja, Rolf Gebhardt, Knut Krohn, Susanne Sales, Kerstin Abshagen, Andrej Shevchenko, Michael Stumvoll, Matthias Blüher, and Nora Klöting: Liver-Restricted Repin1 Deficiency Improves Whole- Body Insulin Sensitivity, Alters Lipid Metabolism, and Causes Secondary Changes in Adipose Tissue in Mice. Diabetes (2014) 63(10): 3295–3309.

Matthias Blüher, Nora Klöting, Stephan Wueest, Eugen J. Schoenle, Michael R. Schön, Arne Dietrich, Mathias Fasshauer, Michael Stumvoll, and Daniel Konrad: Fas and FasL Expression in Human Adipose Tissue Is Related to Obesity, Insulin Resistance, and Type 2 Diabetes. J Clin Endocrinol Metab, (2014) 99(1): E36–E44.

Joanna Krist, Katharina Wieder, Nora Klöting, Andreas Oberbach, Susan Kralisch, Tobias Wiesner, Michael R. Schön, Daniel Gärtner, Arne Dietrich, Edward Shang, Tobias Lohmann, Miriam Dreßler, Mathias Fasshauer, Michael Stumvoll, Matthias Blüher: Effects of Weight Loss and Exercise on Apelin Serum Concentrations and Adipose Tissue Expression in Human Obesity. Obes. Facts (2013) 6(1): 57–69.

Chong Wee Liew, Jeremie Boucher, Jit Kong Cheong, Cecile Vernochet, Ho-Jin Koh, Cristina Mallol, Kristy Townsend, Dominique Langin, Dan Kawamori, Jiang Hu, Yu-Hua Tseng, Marc K Hellerstein, Stephen R Farmer, Laurie Goodyear, Alessandro Doria, Matthias Blüher, Stephen I-Hong Hsu, and Rohit N Kulkarni: Ablation of TRIP-Br2, a novel regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. (2013) 19(2): 217–226.

Thörmer G, Bertram HH, Garnov N, Peter V, Schütz T, Shang E, Blüher M, Kahn T, Busse H.: Software for automated MRI-based quantification of abdominal fat and preliminary evaluation in morbidly obese patients. J Magn Reson Imaging (2013) 37(5): 1144-1150.

Guo-Xiao Wang, Xu-Yun Zhao, Zhuo-Xian Meng, Matthias Kern, Arne Dietrich, Zhimin Chen, Zoharit Cozacov, Dequan Zhou, Adewole L. Okunade, Xiong Su, Siming Li, Matthias Blüher, and Jiandie D. Lin: The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuating hepatic lipogenesis. Nat Med. (2014) 20(12): 1436-1443.

Haiko Schlögl, Stefan Kabisch, Annette Horstmann, Gabriele Lohmann, Karsten Müller, Jöran Lepsien, Franziska Busse-Voigt, Jürgen Kratzsch, Burkhard Pleger, Arno Villringer, Michael Stumvoll: Exenatide-Induced Reduction in Energy Intake Is Associated With Increase in Hypothalamic Connectivity. Diabetes Care (2013) 36(7): 1933–1940.

Julia Haase & Ulrike Weyer & Kerstin Immig & Nora Klöting & Matthias Blüher & Jens Eilers & Ingo Bechmann & Martin Gericke: Local proliferation of macrophages in adipose tissue during obesity-induced inflammation. Diabetologia (2014) 57(3): 562–571.

Chun-Xia Yi, Martin Gericke, Martin Krüger, Anneke Alkemade, Dhiraj G.Kabra, Sophie Hanske, Jessica Filosa, Paul Pfluger, Nathan Bingham, Stephen C.Woods, James Herman, Andries Kalsbeek, Marcus Baumann, Richard Lang, Javier E.Stern, Ingo Bechmann, Matthias H.Tschöp: High calorie diet triggers hypothalamic angiopathy. Mol Metab (2012) 1(1-2): 95-100.

WP 9: Metabolic impact on intestinal stem cell recruitment and turnover; Leader: Heiko Lickert

Moritz Gegg, Anika Böttcher, Ingo Burtscher, Stefan Hasenoeder, Claude Van Campenhout, Michaela Aichler, Axel Walch, Seth G N Grant, Heiko Lickert: Flattop regulates basal body docking and positioning in mono- and multiciliated cells. eLife (2014) 3:e03842.
Adriana Migliorini, ErikBader, Heiko Lickert: Islet cell plasticity and regeneration. Mol. Metab. (2014) 3(3): 268–274.

Dapeng Yang, Dominik Lutter, Ingo Burtscher, Lena Uetzmann, Fabian J. Theis, and Heiko Lickert: miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm. Development (2014) 141(3) 514-525.

Böttcher et al. …….Heiko Lickert.: Wnt/Planar cell polarity signaling regulates cell-cycle exit and lineage commitment of intestinal stem cells.  Under review.

Aliluev et al. …..Heiko Lickert.: Metabolic impact on intestinal stem cell lineage decisions. Manuscript in prep.

Bader et al. ……..Heiko Lickert.: Planar cell polarity underlies cellular heterogeneity in the islet of Langerhans. Under revision.

Sterr et al. ……Heiko Lickert.: Distinct Foxa2 levels regulate intestinal stem cell lineage decisions. Manuscript in prep.

WP 10: Insulin-regulated energy metabolism – cross talk between brain and peripheral tissues; Leader: Michael Roden

Sabine Kahl, Klaus Straßburger, Bettina Nowotny, Roshan Livingstone, Birgit Klüppelholz, Kathrin Keßel, Jong-Hee Hwang, Guido Giani, Barbara Hoffmann, Giovanni Pacini, Amalia Gastaldelli, Michael Roden: Comparison of Liver Fat Indices for the Diagnosis of Hepatic Steatosis and Insulin Resistance. PLoS ONE (2014) 9(4): e94059.

Chrysi Koliaki, Michael Roden: Do mitochondria care about insulin resistance? Mol Metab (2014) 3(4): 351-353.

Sabine Kahl & Bettina Nowotny & Simon Piepel & Peter J. Nowotny & Klaus Strassburger & Christian Herder & Giovanni Pacini & Michael Roden: Estimates of insulin sensitivity from the intravenous-glucose-modified-clamp test depend on suppression of lipolysis in type 2 diabetes: a randomised controlled trial. Diabetologia (2014) 57(10): 2094–2102.

Szendroedi J, Roden M.: Perilipin 5: from fatty liver to hepatic lipodystrophy? Hepatology. (2015) 61(3): 751-753.

Bettina Nowotny & Lejla Zahiragic & Alessandra Bierwagen & Stefan Kabisch & Jan B. Groener & Peter J. Nowotny & Ann Kristin Fleitmann & Christian Herder & Giovanni Pacini & Iris Erlund & Rikard Landberg & Hans-Ulrich Haering & Andreas F. H. Pfeiffer & Peter P. Nawroth & Michael Roden: Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial. Diabetologia (2015) 58(2): 255–264.

Sofiya Gancheva, Chrysi Koliaki, Alessandra Bierwagen, Peter Nowotny, Martin Heni, Andreas Fritsche, Hans-Ulrich Häring, Julia Szendroedi, and Michael Roden: Effects of Intranasal Insulin on Hepatic Fat Accumulation and Energy Metabolism in Humans, Diabetes (2015) 64(6): 1966–1975.

Paul Begovatz & Chrysi Koliaki & Katharina Weber & Klaus Strassburger & Bettina Nowotny & Peter Nowotny & Karsten Müssig & Jürgen Bunke & Giovanni Pacini & Julia Szendrödi & Michael Roden: Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans. Diabetologia (2015) 58(7): 1646–1655.

J. Jones, S. Kahl, F. Carvalho, C. Barosa, M. Roden: Simplified analysis of acetaminophen glucuronide for quantifying gluconeogenesis and glycogenolysis using deuterated water. Analytical Biochemistry (2015) 479: 37–39.

Chrysi Koliaki, Julia Szendroedi, Kirti Kaul, Tomas Jelenik, Peter Nowotny, Frank Jankowiak, Christian Herder, Maren Carstensen, Markus Krausch, Wolfram Trudo Knoefel, Matthias Schlensak, and Michael Roden: Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis. Cell Metabolism (2015) 21(5): 739–746.

Bierwagen A, Begovatz P, Nowotny P, Markgraf D, Nowotny B, Koliaki C, Giani G, Klüppelholz B, Lundbom J, Roden M: Characterization of the peak at 2.06 ppm in (31) P magnetic resonance spectroscopy of human liver: phosphoenolpyruvate or phosphatidylcholine? NMR Biomed. (2015) 28(7): 898-905.

Maria Apostolopoulou, Alberto Corsini, and Michael Roden: The role of mitochondria in statin-induced myopathy. Eur J Clin Invest (2015) 45(7): 745–754.

Michael Roden: Future of muscle research in diabetes: a look into the crystal ball. Diabetologia (2015) 58(8): 1693–1698.

Dan Ziegler, Alexander Strom, Bettina Nowotny, Lejla Zahiragic, Peter J. Nowotny, Maren Carstensen-Kirberg, Christian Herder, and Michael Roden: Effect of Low-Energy Diets Differing in Fiber, Red Meat, and Coffee Intake on Cardiac Autonomic Function in Obese Individuals With Type 2 Diabetes. Diabetes Care (2015) 38(9): 1750–1757.

Olesja Ritter & Tomas Jelenik & Michael Roden: Lipid-mediated muscle insulin resistance: different fat, different pathways? J Mol Med (2015) 93(8): 831–843.

Katharina S. Weber, Bettina Nowotny, Klaus Strassburger, Giovanni Pacini,4 Karsten Müssig, Julia Szendroedi, Christian Herder, and Michael Roden: The Role of Markers of Low-Grade Inflammation for the Early Time Course of Glycemic Control, Glucose Disappearance Rate, and b-Cell Function in Recently Diagnosed Type 1 and Type 2 Diabetes. Diabetes Care (2015) 38(9): 1758–1767.

Fritsch M. …..and Michael Roden.: Time course of postprandial hepatic phosphorus metabolites in lean, obese and type 2 diabetes patients. Am J Clin Nutr accepted.