Research Topic 3: Impaired CNS control of metabolism and therapeutic intervention

ICEMED Publications – Research Topic 3: Impaired CNS control of metabolism and therapeutic intervention; Leaders: Matthias Tschöp, Magdalena Götz

WP 11: Molecular imaging and targeting of hypothalamic inflammation in obestiy; Leader: Jens Brüning

Sophie M. Steculorum, Lars Paeger, Stephan Bremser, Nadine Evers, Yvonne Hinze, Marco Idzko, Peter Kloppenburg, and Jens C. Brüning: Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons. Cell (2015) 162(6): 1404–1417.

Eva Tsaousidou, Lars Paeger, Bengt F. Belgardt, Martin Pal, Claudia M. Wunderlich, Hella Brönneke, Ursel Collienne, Brigitte Hampel, F. Thomas Wunderlich, Marc Schmidt-Supprian, Peter Kloppenburg, and Jens C. Brüning: Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance. Cell Reports (2014) 9(4): 1495–1506.

Sarah M. Turpin, Hayley T. Nicholls, Diana M. Willmes, Arnaud Mourier, Susanne Brodesser, Claudia M. Wunderlich, Jan Mauer, Elaine Xu, Philipp Hammerschmidt, Hella S. Brönneke, Aleksandra Trifunovic, Giuseppe LoSasso, F. Thomas Wunderlich, Jan-Wilhelm Kornfeld, Matthias Blüher, Martin Krönke, and Jens C. Brüning: Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance. Cell Metabolism (2014) 20(4): 678–686.

Merly C. Vogt, Lars Paeger, Simon Hess, Sophie M. Steculorum, Motoharu Awazawa, Brigitte Hampel, Susanne Neupert, Hayley T. Nicholls, Jan Mauer, A. Christine Hausen, Reinhard Predel, Peter Kloppenburg, Tamas L. Horvath, and Jens C. Brüning: Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high fat feeding. Cell (2014) 156(3): 495–509.

WP 12: Dual-specificity phosphatase 8 as molecular link between hypothalamic inflammation and systemic glucose intolerance; Leader:
Matthias Tschöp

Kabra D, et al. ………M.H. Tschöp.: Hypothalamic Leptin Action is Mediated by Histone Deacetylase 5. Nature Neuroscience, in 2nd revision.

Matthias Tschöp, et al. Unimolecular Polypharmacy for Diabetes and Obesity. Cell Metabolism in submission Finan B.,…Tschöp M, Müller T. T3 targeting via glucagon transport offers metabolic benefits without thyrotoxicity Cell in submission

Quarta C. …M.H. Tschöp Gut the munchies? Targeting the intestinal cannabinoid system to control feeding. Cell Preview in submission
Pfluger P, et al. ………..M.H. Tschöp.: Calcineurin links mitochondrial elongation with energy metabolism. Cell Metabolism, in press.

T.D. Müller, R. Nogueiras, M.L. Andermann, Z.B. Andrews, S.D. Anker, J. Argente, R.L. Batterham, S.C. Benoit, C.Y. Bowers, F. Broglio, F.F. Casanueva, D. D’Alessio, I. Depoortere, A. Geliebter, E. Ghigo, P.A. Cole, M. Cowley, D.E. Cummings, A. Dagher, S. Diano, S.L. Dickson, C. Diéguez, R. Granata, H.J. Grill, K. Grove, K.M. Habegger, K. Heppner, M.L. Heiman, L. Holsen, B. Holst, A. Inui, J.O. Jansson, H. Kirchner, M. Korbonits, B. Laferrère, C.W. LeRoux, M. Lopez, S. Morin, M. Nakazato, R. Nass, D. Perez-Tilve, P.T. Pfluger, T.W. Schwartz, R.J. Seeley, M. Sleeman, Y. Sun, L. Sussel, J. Tong, M.O. Thorner, A.J. van der Lely, L.H.T. van der Ploeg, J.M. Zigman, M. Kojima, K. Kangawa, R.G. Smith, T. Horvath, M.H. Tschöp: Ghrelin. MOLECULAR METABOLISM (2015) 4(6): 437-460.

Brian Finan, Bin Yang, Nickki Ottaway, David L Smiley, Tao Ma, Christoffer Clemmensen, Joe Chabenne, Lianshan Zhang, Kirk M Habegger, Katrin Fischer, Jonathan E Campbell, Darleen Sandoval, Randy J Seeley, Konrad Bleicher, Sabine Uhles, William Riboulet, Jürgen Funk, Cornelia Hertel, Sara Belli, Elena Sebokova, Karin Conde-Knape, Anish Konkar, Daniel J Drucker, Vasily Gelfanov, Paul T Pfluger, Timo D Müller, Diego Perez-Tilve, Richard D DiMarchi & Matthias H Tschöp: A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nature Medicine (2015) 21(1): 27-36.

Maarit Lehti, PhD., Elizabeth Donelan, M.S., William Abplanalp, M.S., Omar Al- Massadi, PhD., Kirk Habegger, PhD., Jon Weber, B.S., Chandler Ress, B.S., Johannes Mansfeld, M.S., Sonal Somvanshi, M.S., Chitrang Trivedi, PhD., Michaela Keuper, PhD., Teja Ograjsek, B.S., Cynthia Striese, Sebastian Cucuruz, Paul T. Pfluger, PhD., Radhakrishna Krishna, PhD., Scott M. Gordon, PhD., R. A. Gangani D. Silva, PhD., Serge Luquet, PhD., Julien Castel, PhD., Sarah Martinez, M.S., David D‘Alessio, M.D., W. Sean Davidson, PhD., and Susanna M. Hofmann, M.D.: High-Density Lipoprotein Maintains Skeletal Muscle Function by Modulating Cellular Respiration in Mice. Circulation (2013) 128(22): 2364–2371.

Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968.

WP 13: Dissecting the role of central CRH signalling for hypothalamic inflammatory and morphological processes promoting obesity and diabetes; Leader: Wolfgang Wurst

Annemarie Zimprich, Lillian Garrett, Jan M. Deussing, Carsten T. Wotjak, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Wolfgang Wurst, and Sabine M. Hölter: A robust and reliable non-invasive test for stress responsivity in mice. Frontiers in Behavioral Neuroscience (2014) Article 125, 8: 1-12.

Seyfarth K, Poschmann G, Rozman J, Fromme T, Rink N, Hofmann A, Wurst W, Stühler K, Klingenspor M: The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice. J Nutr Biochem. (2015) 26(1):75-81.

Julia Bender, Maik Engeholm, Marion S. Ederer, Johannes Breu, Thor C. Møller, Stylianos Michalakis, Tamas Rasko, Erich E. Wanker, Martin Biel, Karen L. Martinez, Wolfgang Wurst, Jan M. Deussing: Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. PLoS ONE (2015) 10(9): e0136768.

WP 14: Multi-modal imaging and targeted drug delivery to study diet-induced hypothalamic morphological changes; Leader: Gil Westmeyer

Yuanyuan Jiang, Felix Sigmund, Josefine Reber, Xosé Luís Deán-Ben, Sarah Glasl1, Moritz Kneipp, Héctor Estrada, Daniel Razansky, Vasilis Ntziachristos & Gil G. Westmeyer: Violacein as a geneticallycontrolled, enzymatically amplified and photobleaching-resistant chromophore for optoacoustic bacterial imaging. Scientific Reports (2015) 5:11048.

Stiel AC, Deán-Ben XL, Jiang Y, Ntziachristos V, Razansky D, Westmeyer GG: High-contrast imaging of reversibly switchable fluorescent proteins via temporally unmixed multispectral optoacoustic tomography. Optics Letters (2015) 40(3): 367-370.

Carlos Cruz Perez, Antonella Lauri, Panagiotis Symvoulidis, Michele Cappetta, Arne Erdmann, and Gil Gregor Westmeyer: Calcium neuroimaging in behaving zebrafish larvae using a turn-key light field camera. Journal of Biomedical Optics (2015) 20(9): 096009.

Deán-Ben et al.: Light fluence normalization in turbid tissues via temporally unmixed multispectral optoacoustic tomography. Optics Letters, in press.

Neil Sim, Sven Gottschalk, Robert Pal, Martina Delbianco, Oleksiy Degtyaruk, Daniel Razansky, Gil G. Westmeyer, Vasilis Ntziachristos, David Parker, and Anurag Mishra: Wavelength-dependent optoacoustic imaging probes for NMDA receptor visualisation. Chem. Commun. (2015) September 01. Sela et al.: Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators. In revision.
Mishra, Pariani: Hyperpolarizable chemical shift sensor for metal ion sensing via Magnetic Resonance Spectroscopy. In preparation.

WP 15: Gender-specific effects of endurance training on diet-induced obesity; Leaders: Johannes Beckers, Susanna Hofmann

Michaela Keuper, Martin Jastroch, Chun-Xia Yi, Pamela Fischer-Posovszky, Martin Wabitsch, Matthias H. Tschöp, and Susanna M. Hofmann: Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions. FASEB J. (2014) 28(2): 761–770.

Maarit Lehti, PhD., Elizabeth Donelan, William Abplanalp, Omar Al- Massadi, PhD., Kirk Habegger, Jon Weber, Chandler Ress, Johannes Mansfeld, Sonal Somvanshi, M.S., Chitrang Trivedi, PhD., Michaela Keuper, PhD., Teja Ograjsek, B.S., Cynthia Striese, Sebastian Cucuruz, Paul T. Pfluger, PhD., Radhakrishna Krishna, PhD., Scott M. Gordon, PhD., R. A. Gangani D. Silva, PhD., Serge Luquet, PhD., Julien Castel, PhD., Sarah Martinez, M.S., David D‘Alessio, M.D., W. Sean Davidson, PhD., and Susanna M. Hofmann, M.D.: High-Density Lipoprotein Maintains Skeletal Muscle Function by Modulating Cellular Respiration in Mice. Circulation. (2013) 128(22): 2364–2371.

WP 16: Involvement of a newly discovered endogenous neural stem cell in the CNS control of metabolic diseases; Leaders: Andreas Androutsellis-Theotokis, Stefan Bornstein

Nikolakopoulou et al.: STAT3-Ser/Hes3 Signaling: A new molecular component of the neuroendocrine system?. Endocrinol., submitted.
Masjkur et al.: Endocrine pancreas development and regeneration: Non-canonical ideas from neural stem cell biology. Diabetes, in review.

Poser SW, Chenoweth JG, Colantuoni C, Masjkur J, Chrousos G, Bornstein SR, McKay RD, Androutsellis-Theotokis A: Concise Review: Reprogramming, Behind the Scenes: Non-canonical Neural Stem Cell Signaling Pathways Reveal New, Unseen Regulators of Tissue Plasticity With Therapeutic Implications. Stem Cells Transl Med. (2015) pii: sctm.2015-0105.

Jimmy Masjkur, Carina Arps-Forker, Steven W. Poser, Polyxeni Nikolakopoulou, Louiza Toutouna, Ramu Chenna, Triantafyllos Chavakis, Antonios Chatzigeorgiou, Lan-Sun Chen, Anna Dubrovska, Pratik Choudhary, Ingo Uphues, Michael Mark, Stefan R. Bornstein, and Andreas Androutsellis-Theotokis: Hes3 Is Expressed in the Adult Pancreatic Islet and Regulates Gene Expression, Cell Growth, and Insulin Release. Journal of Biological Chemistry (2014) 289(51): 35503–35516.

Jimmy Masjkur, Ian Levenfus, Sven Lange, Carina Arps-Forker, Steve Poser, Nan Qin, Vladimir Vukicevic, Triantafyllos Chavakis, Graeme Eisenhofer, Stefan R. Bornstein, Monika Ehrhart-Bornstein, Andreas Androutsellis-Theotokis: A Defined, Controlled Culture System for Primary Bovine Chromaffin Progenitors Reveals Novel Biomarkers and Modulators. Stem Cells Translationalmedicine (2014) 3(7): 801–808.

Matina Economopoulou, Jimmy Masjkur, Frederik Raiskup, Doreen Ebermann, Sarama Saha, Mike O. Karl, Richard Funk, Jozsef Jaszai, Triantafyllos Chavakis, Monika Ehrhart-Bornstein, Lutz E. Pillunat, Leoni Kunz-Schughart, Ina Kurth, Anna Dubrovska & Andreas Androutsellis-Theotokis: Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. International Journal of Radiation Biology (2014) 90(8): 700-709.

Poser SW, Park DM, Androutsellis-Theotokis A: The STAT3-Ser/Hes3 signaling axis in cancer. Front Biosci (2014) 19: 718-726.

Poser SW, Rueger MA, Androutsellis-Theotokis A: Methods for assessing the regenerative responses of neural tissue. Methods Mol Biol. (2014) 1213: 293-302.

Poser SW, Androutsellis-Theotokis A: Growing neural stem cells from conventional and nonconventional regions of the adult rodent brain. J Vis Exp. (2013) (81): e50880.

Steven W. Poser, Deric M. Park, and Andreas Androutsellis-Theotokis: The STAT3-Ser/Hes3 signaling axis: an emerging regulator of endogenous regeneration and cancer growth. Frontiers in Physiology (2013) Article 273, 4: 1-7.

WP 17: Impact of metabolic diseases on adult neural stem cells in hypothalamic metabolism control centers; Leader: Magdalena Götz

Robins SC, Stewart I, McNay DE, Taylor V, Giachino C, Goetz M, Ninkovic J, Briancon N, Maratos-Flier E, Flier JS, Kokoeva MV, Placzek M. α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors. Nat Commun. 2013;4:2049. doi: 10.1038/ncomms3049.

Bardehle S, Krüger M, Buggenthin F, Schwausch J, Ninkovic J, Clevers H, Snippert HJ, Theis FJ, Meyer-Luehmann M, Bechmann I, Dimou L, Götz M Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nat Neurosci. 2013 May;16(5):580-6. doi: 10.1038/nn.3371. Epub 2013 Mar 31.
Sirko et al. The stem cell response of reactive glia differs in diverse injury paradigms revealing a key role of sonic hedgehog. Cell Stem Cell Bardehle S et al. In vivo imaging reveals astrocyte proliferation in a vascular niche. Nature Neurosci.

Behrendt G, Baer K, Buffo A, Curtis MA, Faull RL, Rees MI, Götz M, Dimou L. Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men. Glia. 2013 Feb;61(2):273-86. doi: 10.1002/glia.22432. Epub 2012 Oct 22.

Beckervordersandforth R, Deshpande A, Schäffner I, Huttner HB, Lepier A, Lie DC, Götz M In vivo targeting of adult neural stem cells in the dentate gyrus by a split-cre approach. Stem Cell Reports. 2014 Feb 6;2(2):153-62. doi: 10.1016/j.stemcr.2014.01.004. eCollection 2014.

Heinrich C, Bergami M, Gascón S, Lepier A, Viganò F, Dimou L, Sutor B, Berninger B, Götz M Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex. Stem Cell Reports. 2014 Dec 9;3(6):1000-14. doi: 10.1016/j.stemcr.2014.10.007. Epub 2014 Nov 20.

Bergami M, Masserdotti G, Temprana SG, Motori E, Eriksson TM, Göbel J, Yang SM, Conzelmann KK, Schinder AF, Götz M, Berninger B. A critical period for experience-dependent remodeling of adult-born neuron connectivity. Neuron. 2015 Feb 18;85(4):710-7. doi: 10.1016/j.neuron.2015.01.001. Epub 2015 Feb 5.

Calzolari F, Michel J, Baumgart EV, Theis F, Götz M, Ninkovic J. Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone. Nat Neurosci. 2015 Apr;18(4):490-2. doi: 10.1038/nn.3963. Epub 2015 Mar 2.

Barbosa JS, Sanchez-Gonzalez R, Di Giaimo R, Baumgart EV, Theis FJ, Götz M, Ninkovic J. Neurodevelopment. Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain. Science. 2015 May 15;348(6236):789-93. doi: 10.1126/science.aaa2729.

Masserdotti G, Gillotin S, Sutor B, Drechsel D, Irmler M, Jørgensen HF, Sass S, Theis FJ, Beckers J, Berninger B, Guillemot F, Götz M. Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes. Cell Stem Cell. 2015 Jul 2;17(1):74-88. doi: 10.1016/j.stem.2015.05.014. Epub 2015 Jun 25.

Sirko S, Irmler M, Gascón S, Bek S, Schneider S, Dimou L, Obermann J, De Souza Paiva D, Poirier F, Beckers J, Hauck SM, Barde YA, Götz M. Astrocyte reactivity after brain injury-: The role of galectins 1 and 3. Glia. 2015 Dec;63(12):2340-61. doi: 10.1002/glia.22898. Epub 2015 Aug 6.

Gascon … Götz M. Identification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming. Cell Stem Cell, in revision

WP 18: Brain insulin action in the control of systemic glucose and energy metabolism; Leaders: Manfred Hallschmid, Hendrik Lehnert, Hans-Ulrich Häring

Ehses P, Bause J, Shajan G, Scheffler K: Efficient generation of T2*-weighted contrast by interslice echo-shifting for human functional and anatomical imaging at 9.4 Tesla. Magn Reson Med. (2014) Dec 2.
Thomas Benkert, Philipp Ehses, Martin Blaimer, Peter M. Jakob, and Felix A. Breuer: Dynamically Phase-Cycled Radial Balanced SSFP Imaging for Efficient Banding Removal. Magnetic Resonance in Medicine (2014) 73: 182–194.

Benkert T, Ehses P, Blaimer M, Jakob PM, Breuer FA: Fast isotropic banding-free bSSFP imaging using 3D dynamically phase-cycled radial bSSFP (3D DYPR-SSFP). Z Med Phys. (2015) Jun 25.

Scheffler K, Ehses P: High-resolution mapping of neuronal activation with balanced SSFP at 9.4 tesla. Magn Reson Med. (2015) Aug 24.

Stephanie Kullmann, Martin Heni, Ralf Veit, Klaus Scheffler, Jürgen Machann, Hans-Ulrich Häring, Andreas Fritsche, and Hubert Preissl: Selective Insulin Resistance in Homeostatic and Cognitive Control Brain Areas in Overweight and Obese Adults. Diabetes Care (2015) 38(6): 1044–1050.

Ehses P, ChadzynskiGL, Scheffler K: Fast and efficient free induction decay proton MRSI in the human brain at 9.4 T. Submitted.

Bause J, Ehese P, Bartels A, Pohmann R, Scheffler K: Distortion and prospective motion corrected zoomed functional imaging of the human visual cortex at 9.4 T. Submitted.

Feld GB, Wilhelm I, Benedict C, Rüdel B, Klameth C, Born J, Hallschmid M: Central nervous insulin signaling in sleep-dependent memory formation and neuroendocrine regulation. Submitted.

Heni M, Kullmann S, Wagner R, Machicao F, Staiger H, Häring HU, Small DM, Fritsche A, Preissl H: Evidence for an interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA. Submitted.

Krug R, Ott V, Mohwinkel L, Born J, Hallschmid M: Insulin and estrogen independently and differentially reduce macronutrient intake in healthy men. Submitted.

Kullmann S, Heni M, Hallschmid M, Preissl H., Fritsche A, Häring HU: Brain insulin resistance on the crossroad of metabolism and cognitive dysfunction in humans. Physiol Rev (invited).

Kullmann S, Callaghan MF, Heni, M, Weiskopf N, Häring HU, Scheffler K, Fritsche A, Veit R, Preissl H: Obesity associated changes in specific white matter tissue microstructure. Neuroimage, in revision.

Thienel M, Fritsche A, Heinrichs M, Ewers M, Born J, Hallschmid M: Oxytocin inhibits food intake in obese men. Submitted.

Sofiya Gancheva, Chrysi Koliaki, Alessandra Bierwagen, Peter Nowotny, Martin Heni, Andreas Fritsche, Hans-Ulrich Häring, Julia Szendroedi, and Michael Roden: Effects of Intranasal Insulin on Hepatic Fat Accumulation and Energy Metabolism in Humans. Diabetes (2015) 64(6): 1966–1975.

Heni M, Kullmann S, Preissl H., Fritsche A, Häring HU: Impaired insulin action in the human brain: Causes and metabolic consequences. Nature Rev Endocrinol (2015) accepted.

Kullmann S, Schweizer F, Veit R, Fritsche A, Preissl H.: Compromised white matter integrity in obesity. Obes Rev. (2015) 16(4): 273-281.

S. Kullmann, M. Heni, A. Fritsche, and H. Preissl: Insulin Action in the Human Brain: Evidence from Neuroimaging Studies. Journal of Neuroendocrinology (2015) 27(6): 419–423.

Volker Ott, Hendrik Lehnert, Josefine Staub, Kathrin Wönne, Jan Born, and Manfred Hallschmid: Central Nervous Insulin Administration Does Not Potentiate the Acute Glucoregulatory Impact of Concurrent Mild Hyperinsulinemia. Diabetes (2015) 64(3): 760–765

Schmid SM, Hallschmid M, Schultes B: The metabolic burden of sleep loss. Lancet Diabetes Endocrinol. (2015) 3(1): 52-62.

Maartje S. Spetter, and Manfred Hallschmid: Intranasal Neuropeptide Administration To Target the Human Brain in Health and Disease. Mol. Pharmaceutics (2015) 12(8): 2767−2780.

Martin Heni, Robert Wagner, Stephanie Kullmann, Hubert Preissl, and Andreas Fritsche: Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men. Diabetes (2014) 63(12): 4083–4088.

K. Alexander Iwen, Thomas Scherer, Martin Heni, Friedhelm Sayk, Toni Wellnitz, Felix Machleidt, Hubert Preissl, Hans-Ulrich Häring, Andreas Fritsche, Hendrik Lehnert, Christoph Buettner, and Manfred Hallschmid: Intranasal Insulin Suppresses Systemic but Not Subcutaneous Lipolysis in Healthy Humans. J Clin Endocrinol Metab. (2014) 99(2): E246–E251.

Kullmann S, Heni M, Linder K, Zipfel S, Häring HU, Veit R, Fritsche A, Preissl H.: Resting-state functional connectivity of the human hypothalamus. Hum Brain Mapp. (2014) 35(12): 6088-6096.

Ralf Veit, Stephanie Kullmanna, Martin Heni, Jürgen Machannb, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preissl: Reduced cortical thickness associated with visceral fat and BMI. NeuroImage: Clinical (2014) 6: 307–311.

Jessica Freiherr, Manfred Hallschmid, William H. Frey II, Yvonne F. Brünner, Colin D. Chapman, Christian Hölscher, Suzanne Craft, Fernanda G. De Felice, Christian Benedict: Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence. CNS Drugs (2013) 27(7): 505–514.

Martin Heni, Stephanie Kullmann, Ralf Veit, Caroline Ketterer, Sabine Frank, Fausto Machicao, Harald Staiger, Hans-Ulrich Häring, Hubert Preissl, Andreas Fritsche: Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex. Molecular Metabaolism (2014) 3(2): 109–113.

Volker Ott, Graham Finlayson, Hendrik Lehnert, Birte Heitmann, Markus Heinrichs, Jan Born, and Manfred Hallschmid: Oxytocin Reduces Reward-Driven Food Intake in Humans. Diabetes (2013) 62(10): 3418–3425.

WP 19: Interaction between nutrition and the endocrine network regulating whole body energy homeostasis; Leaders: Joachim Spranger, Heiko Krude, Heike Biebermann, John Haynes

Anne Müller, Gunnar Kleinau, Carolin L. Piechowski, Timo D. Müller, Brian Finan, Juliane Pratzka, Annette Grüters, Heiko Krude, Matthias Tschöp, Heike Biebermann: G-Protein Coupled Receptor 83 (GPR83) Signaling Determined by Constitutive and Zinc(II)-Induced Activity. PLoS ONE (2013) 8(1): e53347.

Timo D. Müller, Anne Müller, Chun-Xia Yi, Kirk M. Habegger, Carola W. Meyer, Bruce D. Gaylinn, Brian Finan, Kristy Heppner, Chitrang Trivedi, Maximilian Bielohuby, William Abplanalp, Franziska Meyer, Carolin L. Piechowski, Juliane Pratzka, Kerstin Stemmer, Jenna Holland, Jazzmin Hembree, Nakul Bhardwaj, Christine Raver, Nickki Ottaway, Radha Krishna, Renu Sah, Floyd R. Sallee, Stephen C. Woods, Diego Perez-Tilve, Martin Bidlingmaier, Michael O. Thorner, Heiko Krude, David Smiley, Richard DiMarchi, Susanna Hofmann, Paul T. Pfluger, Gunnar Kleinau, Heike Biebermann & Matthias H. Tschöp: The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nature Communications (2013) 4: 1968.

Anne Müller, Brinja Leinweber, Jana Fischer, Timo D Müller, Annette Grüters, Matthias H Tschöp, Vera Knäuper, Heike Biebermann, and Gunnar Kleinau: The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist. BMC Research Notes (2014) 7: 913.

Martin Weygandt, Knut Mai, Esther Dommes, Kerstin Ritter, Verena Leupelt, Joachim Spranger, John-Dylan Haynes: Impulse control in the dorsolateral prefrontal cortex counteracts post-diet weight regain in obesity. NeuroImage (2015) 109: 318–327.

Martin Weygandt, Knut Mai, Esther Dommes, Verena Leupelt, Kerstin Hackmack, Thorsten Kahnt, Yvonne Rothemund, Joachim Spranger, John-Dylan Haynes: The role of neural impulse control mechanisms for dietary success in obesity. NeuroImage (2013) 83: 669–678.