Research Topic 4: Next generation CNS Imaging for metabolic disease

ICEMED Publications – Research Topic 4: Next generation CNS Imaging for metabolic disease; Leader: Jon Shah

WP 20: Development of 23Na Imaging methodology and applications; Leaders: Thoralf Niendorf, Mark Ladd, Jon Shah, Klaus Scheffler

Feutlinske F, Browarski M, Ku MC, Trnka P, Waiczies S, Niendorf T, Stallcup WB, Glass R, Krause E, Maritzen T. Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility. Nat Commun. 2015 Oct 5;6:8535. doi: 10.1038/ncomms9535.

Reimann, Henschel, Marek, Huelnhagen, Todiras, Kox, Waiczies, Bader, Hodge, Pohlmann, Niendorf: Normothermic Mouse Functional MRI of Acute Focal Thermostimulation for Probing Nociception. Scienific Reports 2015 R1, in revision

Graessl A, Ruehle A, Waiczies H, Resetar A, Hoffmann SH, Rieger J, Wetterling F, Winter L, Nagel AM, Niendorf T: Sodium MRI of the human heart at 7.0 T: preliminary results. NMR Biomed. (2015) 28(8): 967-975.

Resetar A, Hoffmann SH, Graessl A, Winter L, Waiczies H, Ladd ME, Niendorf T, Nagel AM. Retrospectively-gated CINE 23Na imaging of the heart at 7.0Tesla using density-adapted 3D projection reconstruction. Magn Reson Imaging. (2015) Jun 25. pii: S0730-725X(15)00157-5. doi: 10.1016/j.mri.2015.06.012. [Epub ahead of print].

Oezerdem C, Winter L, Graessl A, Paul K, Els A, Weinberger O, Rieger J, Kuehne A, Dieringer M, Hezel F, Voit D, Frahm J, Niendorf T: 16-channel bow tie antenna transceiver array for cardiac MR at 7.0 tesla. Magn Reson Med. (2015) Jul 17. doi: 10.1002/mrm.25840. [Epub ahead of print].

Niendorf T, Paul K, Oezerdem C, Graessl A, Klix S, Huelnhagen T, Hezel F, Rieger J, Waiczies H, Frahm J, Nagel AM, Oberacker E, Winter L. W(h)ither human cardiac and body magnetic resonance at ultrahigh fields? technical advances, practical considerations, applications, and clinical opportunities. NMR Biomed. (2015) Feb 23. doi: 10.1002/nbm.3268. [Epub ahead of print].

Paul, Graessl, Rieger, Lysiak, Huelnhagen, Winter, Heidemann, Lindner, Hadlich, Zimpfer, Pohlmann, Endemann, Kruger, Langner, Stachs, Niendorf: Diffusion-sensitized ophthalmic magnetic resonance imaging free of geometric distortion at 3.0 and 7.0 T: a feasibility study in healthy subjects and patients with intraocular masses. Invest Radiol (2015) 50(5): 309-321.

Linz, Santoro, Renz, Rieger, Ruehle, Ruff, Deimling, Rakova, Muller, Luft, Titze, Niendorf: Skin sodium measured with (23) Na MRI at 7.0 T. NMR Biomed (2015) 28(1): 54-62.

Klix, Els, Paul, Graessl, Oezerdem, Weinberger, Winter, Thalhammer, Huelnhagen, Rieger, Mehling, Schulz-Menger, Niendorf: On the Subjective Acceptance during Cardiovascular Magnetic Resonance Imaging at 7.0 Tesla. PLoS One (2015) 10(1): e0117095.

Winter, Oberacker, Ozerdem, Ji, von Knobelsdorff-Brenkenhoff, Weidemann, Ittermann, Seifert, Niendorf: On the RF heating of coronary stents at 7.0 Tesla MRI. Magn Reson Med (2014) doi: 101002/mrm25483 [Epub ahead of print].

Behl, Gnahm, Bachert, Ladd, Nagel: Three-dimensional dictionary-learning reconstruction of Na MRI data. Magn Reson Med (2015) doi: 10.1002/mrm.25759. [Epub ahead of print].

Gnahm, Nagel.: Anatomically weighted second-order total variation reconstruction of 23Na MRI using prior information from 1H MRI. NeuroImage (2015) 105: 452-461.

Rink, Berger, Korzowski, Breithaupt, Biller, Bachert, Nagel.: Nuclear-Overhauser-enhanced MR imaging of P-containing metabolites: multipoint-Dixon vs. frequency-selective excitation. Magnetic Reson Imaging (2015) doi: 10.1016/j.mri. 2015.07.017 [Epub ahead of print].
Nagel, Lehmann-Horn, Weber, Jurkat-Rott, Wolf, Radbruch, Umathum, Semmler: In vivo 35Cl MR imaging in humans: a feasibility study. Radiology (2014) 271(2): 585-595.

Romanzetti S, Mirkes CC, Fiege D , Celik A , Felder J and Shah NJ.: Mapping tissue sodium concentration in the human brain: A comparison of MR sequences at 9.4 Tesla. NeuroImage (2014) 96, 44–53.
Mirkes CC, Hoffmann J, Shajan G, Pohmann R and Scheffler K: High-resolution quantitative sodium imaging at 9.4 Tesla. Magn Reson Med, (2014) 73: 342–351.

Shajan G , Mirkes C , Buckenmaier K , Hoffmann J , Pohmann R and Scheffler K.: A Three-layered RF Coil Arrangement for Sodium MRI of the Human Brain at 9.4 Tesla. Magn Reson Med. (2015) Mar 11.

Mirkes C, Shajan G, Bause J, Buckenmaier K, Hoffmann J, and Scheffler K: Triple-Quantum-Filtered Sodium Imaging at 9.4 Tesla. Magn Reson Med. (2015) Apr 4.

WP 22: MR-PET an 31P Spectroscopy at 9.4T; Leaders: Jon Shah, Klaus Scheffler, Neuner, Oros-Peusquens

Mirkes CC, Shajan G, Pohmann R, Scheffler K: Phosphorus 3D CSI at 9.4 T using a 27-channel Receiver array. Submitted.

WP 23: Adipose Tissue; Leader: Jürgen Hennig

Ludwig U, Klausmann F, Baumann S, Honal M, Hövener JB, König D, Deibert P, Büchert M: Whole-body MRI-based fat quantification: a comparison to air displacement plethysmography. J Magn Reson Imag (2014) 40(6): 1437-1444.

Lange T, Buechert M, Baumstark MW, Deibert P, Gerner S, Rydén H, Seufert J, Korsten-Reck: Value of MRI and MRS fat measurements to complement conventional screening methods for childhood obesity. J Magn Reson Imaging. (2015) doi: 10.1002/jmri.24919. [Epub ahead of print].

Haas M., Ullmann P., Schneider J. T., Post H., Ruhm W., Hennig J., Zaitsev M.: PexLoc-Parallel excitation using local encoding magnetic fields with nonlinear and nonbijective spatial profiles. Magn Reson Med, (2013) 70 (5): 1220-1228.

WP 24: Structural and functional imaging at ultra high-fields; Leaders: Jon Shah, Harald Moeller, Oros-Peusquens

I Neuner ……N. Jon Shah: The default mode network and EEG regional spectral power: a simultaneous fMRI-EEG study. PLoS One (2014) 9(2): e88214.

N. Jon Shah: Multimodal neuroimaging in humans at 9.4T: a technological breakthrough towards an advanced metabolic imaging scanner. Brain Struct Funct (2014) 220(4): 1867-1884.

N. Jon Shah: Effects of Magnetic Fields of up to 9.4 T on Resolution and Contrast of PET Images as Measured with an MR-BrainPET. PLoS One (2014) 9(4): e95250.

C Wyss …….N. Jon Shah: Spatiotemporal properties of auditory intensity processing in multisensor MEG. NeuroImage (2014) 2: 465-473.

Rosenberg J ……N. Jon Shah: Early to bed, early to rise: diffusion tensor imaging identifies chronotype-specificity. NeuroImage (2014) 84: 428-434.

Ke Zhang ……N. Jon Shah: Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labelling magnetic resonance imaging. J Cereb Blood Flow Metab (2014) 34(8): 1373-1380.

K Reetz and Zaheer Abbas …….N. Jon Shah: Increased Cerebral Water Content in Hemodialysis Patients. PLoS One (2015) 10(3): e0122188.
Zaheer Abbas …….N. Jon Shah: Analysis of proton-density bias corrections based on T1 measurement for robust quantification of water content in the brain at 3 Tesla. Magn Reson med (2014) 72(6): 1735-1745.

J Lindemeyer ……..N. Jon Shah: Multistage Background Field Removal (MUBAFIRE) – Compensating for B0 Distortions at Ultra-High Field. PloS One Accepted (2015).

N. Jon Shah: Imaging of Sodium in the Brain: a Brief Review. NMR Biomed. Accepted (2015).

A.M. Oros-Peusquens, and N.J. Shah A seven-minute protocol for quantitative, whole-brain, accurate water content mapping at 3T for neuroscientific applications. Plos One submitted

A.M. Oros-Peusquens, and N.J. Shah: High-resolution and quantitative imaging of the post mortem brain. NeuroImage. submitted

D.K. Müller, A. Pampel, H.E. Möller: Matrix-algebra-based calculations of the time evolution of the binary spin-bath model for magnetization transfer. Journal of Magnetic Resonance (2013) 230: 88-97.

C. Labadie, S. Hetzer, J. Schulz, et al.: Center-out echo-planar spectroscopic imaging with correction of gradient-echo phase and time shifts. Magnetic Resonance in Medicine (2013) 70(1): 16-24.

C. Labadie, J.H. Lee, W. D. Rooney, et al.: Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields. Magnetic Resonance in Medicine (2014) 71(1): 375-387.

D.P. Streitbürger, A. Pampel, et al. ……Möller, H.E.: Impact of image acquisition on voxel-based-morphometry investigations of age-related structural brain changes. NeuroImage (2014) 87: 170-182.

K. Mueller, A. Horstmann, H.E. Möller, et al.: Obesity associated cerebral gray and white matter alterations are interrelated in the female brain. PLoS ONE (2014) 9(12): e114206.

Pampel, D.K. Müller, A. Anwander, Marschner H., H.E. Möller, et al.: Orientation dependence of magnetization transfer parameters in human white matter. NeuroImage (2015) 114: 136-146.

K. Mueller, H.E. Möller, A. Horstmann, et al. Physical exercise in overweight to obese individuals induces metabolic- and neurotropic-related structural brain plasticity. Frontiers in Human Neuroscience (2015) 9: 372.

K. Mueller, K. Arelin, H. E. Möller, J. Kratzsch, T. Luck, et al.: Serum BDNF correlates with connectivity in the (pre)motor hub in the aging human brain—A resting state fMRI pilot study. Neurobiology of Aging (submitted).

B. Dhital, C. Labadie, et al.: Temperature dependence of water diffusion pools in brain white matter. NeuroImage (submitted).

E. Kuehn, J. Dinse, et al.: Mind the gap – Septa demarcate body parts in human sensorimotor cortex.. Neuron (submitted).

R. Metere, H.E. Möller, T. Kober, et al.: Simultaneous quantitative mapping of T1, T2*, and magnetic susceptibility with multi-echo MP2RAGE at 7 T. NeuroImage (submitted).

WP 25: Changes in glutamate and GABA measured with proton magnetic resoncance spectroscopy at 7T in the brains of patients with T2DM treatd with nasally administered insulin; Leaders: Norris, Wiltfang, Brand,
Tendolkar, Schulz

Thielen et al.: Transient relay function of midline thalamic nuclei during long-term memory consolidation in humans. Learning & Memory in press (2015).

Thielen et al.: Aerobic but not general physical activity in the healthy elderly is associated with larger plasticity in memory related brain structures and lower systemic inflammation. Journal of Cognitive Neuroscience under review.

Thielen et al.: The interaction of GABA/Glutamate with the episodic memory network. Journal of Neuroscience submitted.